Nucleocapsid phosphoprotein – Communicable Diseases Research

Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein

엽산: SARS-CoV-2 뉴클레오캡시드 단백질에 대한 잠재적 억제제

Article

Published on 2022-12-012022-09-11
Journal: Pharmaceutical Biology
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법,

Cross-Reactivity of SARS-CoV-2 Nucleocapsid-Binding Antibodies and Its Implication for COVID-19 Serology Tests

Article

Published on 2022-09-142022-11-15
Journal: Viruses
[Category] SARS, 변종, 진단, 치료기술,

Probing the mutation independent interaction of DNA probes with SARS-CoV-2 variants through a combination of surface-enhanced Raman scattering and machine learning

표면 강화 라만 산란 및 기계 학습의 조합을 통해 SARS-CoV-2 변이체와 DNA 프로브의 돌연변이 독립적 상호작용 조사

Article

Published on 2022-07-152022-09-11
Journal: Biosensors & bioelectronics
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antigenicity antisense Antisense oligonucleotide Antisense oligonucleotides ASO binding efficiency Characteristics characterized clinically Combination Concentration coronavirus described detect develop diagnostic diagnostic test DNA Evolution Genetic human population hypothetical Immune profile independent Interaction mechanism mutate Mutation Mutation resistant probe mutations N gene negative sample nucleocapsid Nucleocapsid phosphoprotein Point mutation positive probe probes Probing reveal RNA SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus scattering Selective and ultrasensitive diagnosis sensitivity sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specificity surface-Enhanced Raman scattering. technique the SARS-CoV-2 virus therapeutic Transmissibility unique variants virus
[DOI] 10.1016/j.bios.2022.114200 PMC 바로가기 [Article Type] Article

Immunological investigation of a multiepitope peptide vaccine candidate based on main proteins of SARS-CoV-2 pathogen

SARS-CoV-2 병원체의 주요 단백질에 기반한 다중 에피토프 펩타이드 백신 후보의 면역학적 조사

Article

Published on 2022-06-092022-09-11
Journal: PLoS ONE
[Category] COVID19(2023년), SARS, 변종, 치료법,

[키워드] antigenic Cell complex cytotoxic T lymphocyte develop DNA E. coli Epitopes eukaryotic evaluated expression expression vectors granzyme granzyme B groups helper T lymphocyte Heterologous homologous IFN-γ IgG IgG2a IL-15 IL-21 IL-6 immune response immune responses Immunity immunized in silico in vitro in vivo indicated induce linear B linear B lymphocyte lymphocyte mammalian cell membrane protein mice multiepitope peptide vaccine multiepitope vaccine Multiepitope vaccines nucleocapsid Nucleocapsid phosphoprotein pathogen Pathogens pcDNA3.1 Penetrating peptide produced Protein regimen regimens SARS-CoV-2 SARS-COV-2 infection secretion significantly spike glycoprotein stimulated subcloned T lymphocyte target targets TNF-α Vaccine vaccine candidate variants were used
[DOI] 10.1371/journal.pone.0268251 PMC 바로가기 [Article Type] Article

Immunogenic SARS-CoV-2 S and N Protein Peptide and Cytokine Combinations as Biomarkers for Early Prediction of Fatal COVID-19

치명적인 COVID-19의 조기 예측을 위한 바이오마커로서의 면역원성 SARS-CoV-2 S 및 N 단백질 펩티드 및 사이토카인 조합

Article

Published on 2022-03-212022-09-11
Journal: Frontiers in Immunology
[Category] MERS, SARS, 바이오마커, 진단, 치료법,

[키워드] Activation analyzed Biomarker Biomarkers chemokines clinical outcomes convalescent COVID-19 patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 sera cytokine Cytokine activation Cytokines demonstrated difference fatal fatal COVID-19 fatality higher risk highest humoral immune response IgG IgM IgM antibody improve clinical outcomes indication knowledge likelihood longitudinal analysis marker N protein nucleocapsid Nucleocapsid phosphoprotein Patient peptide peptide. peptides prediction pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines quantified reactivity risk S protein SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 S selected serum serum sample serum samples severe coronavirus disease Surface glycoprotein Treatment
[DOI] 10.3389/fimmu.2022.830715 PMC 바로가기 [Article Type] Article

A Global Mutational Profile of SARS-CoV-2: A Systematic Review and Meta-Analysis of 368,316 COVID-19 Patients

Systematic Review

Published on 2021-11-112022-10-29
Journal: International Review of Cell and Molecular Biology
[Category] COVID-19,

T-cell responses to SARS-CoV-2 in multiple sclerosis patients treated with ocrelizumab healed from COVID-19 with absent or low anti-spike antibody titers

코로나19에서 치유된 오크렐리주맙 치료를 받은 다발성 경화증 환자의 SARS-CoV-2에 대한 T-세포 반응

Article

Published on 2021-10-012022-09-11
Journal: Multiple sclerosis and related disorders
[Category] MERS, 진단, 치료법,

[키워드] abrogate absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 anti-S anti-SARS-CoV-2 antibody anti-spike antibody antibodies approach B-cell CD20 CD4/CD8 Concentration Coronavirus-2 COVID-19 depleting detect detectable diagnostic Disease modifying therapies domain enrolled FIVE glycoprotein IGRA immune response immunodominant Immunological response impair IMPROVE interferon Interferon-gamma multiple sclerosis natural infection not affect Nucleocapsid phosphoprotein Ocrelizumab Patient patients patients treated peptide peptides Peripheral blood receiving reduce reduction respiratory SARS-CoV-2 SARS-COV-2 infection sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Specific T-cell response spike glycoprotein Stimulation subset T-cell Response T-cell responses T-lymphocyte T-lymphocyte, peptides. the Spike therapy Treatment vaccination Whole blood
[DOI] 10.1016/j.msard.2021.103157 PMC 바로가기 [Article Type] Article

Targeting of Protein’s Messenger RNA for Viral Replication, Assembly and Release in SARS-CoV-2 Using Whole Genomic Data From South Africa: Therapeutic Potentials of Cannabis Sativa L

Pharmacology

Published on 2021-09-022022-10-31
Journal: Frontiers in Pharmacology
[Category] COVID-19,

[키워드] activity Analysis assembly attack bat binding affinity cannabinol cannabis Cannabis sativa China Clinical studies coding computational tools country COVID-19 docking envelope Genome glycoprotein homology IBV implicated in viral Interaction investigated Italy MERS-CoV messenger MHV Middle East mouse mRNA mRNAs Nucleocapsid phosphoprotein ORF1ab other coronaviruses Patient phytocannabinoids Potential potential therapy Protein Release Replication respiratory RNA SARS CoV SARS-CoV-2 South South Africa Spain Spectroscopy Spread surface targeting translation United States viral nucleotide whole genome
[DOI] 10.3389/fphar.2021.736511 PMC 바로가기 [Article Type] Pharmacology

Development of a Smartphone-Based Nanozyme-Linked Immunosorbent Assay for Quantitative Detection of SARS-CoV-2 Nucleocapsid Phosphoprotein in Blood

Microbiology

Published on 2021-08-232022-10-31
Journal: Frontiers in Microbiology
[Category] COVID-19,

Virtual screening and dynamics of potential inhibitors targeting RNA binding domain of nucleocapsid phosphoprotein from SARS-CoV-2

SARS-CoV-2의 뉴클레오캡시드 인단백질의 RNA 결합 도메인을 표적으로 하는 잠재적 억제제의 가상 스크리닝 및 역학

Article

Published on 2021-08-012022-09-11
Journal: Journal of biomolecular structure & dynamics
[Category] SARS, 유전자 메커니즘, 치료법,

[키워드] Antiviral binding binding domain binding energy binding free energy calculated coronavirus coronavirus disease COVID-19 database databases docking docking process docking score docking scores drug exonuclease fluctuation genetic material hotspot inhibitor Interaction Ligand mechanism molecular molecular dynamics Molecular dynamics simulation N protein nucleocapsid Nucleocapsid phosphoprotein nucleocapsid phosphoprotein. outbreak pandemic Potential treatment Precision PubChem PubChem database remained required RMSD RMSF RNA SARS-CoV-2 selected Site target target protein transcribed Transcription unique viral replication virion Virtual screening virus zidovudine
[DOI] 10.1080/07391102.2020.1778536 PMC 바로가기 [Article Type] Article